DMT-2'-O-TBDMS-C(Ac)-CE Phosphoramidite Cap Analogs and the methyl donor (SAM)

and the methyl donor (SAM)

pseudouridine can reduce innate immune recognition compared with unmodified uridine and improve RNA stability and translational performance

It can resist degradation by nucleases

a 2’-O-tert-butyldimethylsilyl (TBDMS) protecting group for 2’-hydroxyl protection

"translational GTPases

DMT-2'-O-TBDMS-C(Ac)-CE Phosphoramidite Cap Analogs and the methyl donor (SAM)DMT 2' O TBDMS C(Ac) CE Phosphoramidite is a protected ribonucleoside building block used for solid phase RNA oligonucleotide synthesis. It contains a 5' dimethoxytrityl (DMT) protecting group for 5' hydroxyl protection, a 2' O tert butyldimethylsilyl (TBDMS) protecting group for 2' hydroxyl protection, a cyanoethyl (CE) protecting group on phosphite, and a acetyl (Ac) base protecting group on cytosine. TBDMS offers excellent stability for protecting